QIAD assay for quantitating a compound`s efficacy in elimination of toxic Aß oligomers

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Table (21)
Contents (21)

 name link intern personenkennziffer
0 Oleksandr Brener false 
1 Tina Dunkelmann false 
2 Lothar Gremer false 
3 Thomas van Groen false 
4 Ewa A. Mirecka false 
5 Inga Kadish false 
6 Antje Willuweit false 
7 Janine Kutzsche false 
8 Dagmar Jürgens false 
9 Stephan Rudolph false 
10 Markus Tusche false 
11 Patrick Bongen false 
12 Jörg Pietruszka false 
13 Filipp Oesterhelt false 
14 Karl-Josef Langen false 
15 Hans-Ulrich Demuth false 
16 Arnold Janssen false 
17 Wolfgang Hoyer false 
18 Susanne Aileen Funke https://www.hs-coburg.de/personen/prof-dr-susanne-aileen-funke/ true 
19 Luitgard Nagel-Steger false 
20 Dieter Willbold false

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0 => array (4)
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⇄name => string (16) "Oleksandr Brener"
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⇄name => string (15) "Tina Dunkelmann"
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2 => array (4)
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⇄name => string (13) "Lothar Gremer"
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⇄⧉
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⇄name => string (16) "Thomas van Groen"
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⇄name => string (14) "Ewa A. Mirecka"
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⇄⧉
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⇄name => string (15) "Janine Kutzsche"
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⇄name => UTF-8 string (15) "Dagmar Jürgens"
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12 => array (4)
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⇄name => UTF-8 string (16) "Jörg Pietruszka"
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⇄name => string (17) "Karl-Josef Langen"
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⇄name => string (18) "Hans-Ulrich Demuth"
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⇄name => string (14) "Arnold Janssen"
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⇄name => string (14) "Wolfgang Hoyer"
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⇄⧉
18 => array (4)
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⇄name => string (20) "Susanne Aileen Funke"
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⇄link => string (63) "https://www.hs-coburg.de/personen/prof-dr-susanne-aileen-funke/"
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19 => array (4)
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⇄name => string (21) "Luitgard Nagel-Steger"
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20 => array (4)
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	name	link	intern
0	Oleksandr Brener		`false`
1	Tina Dunkelmann		`false`
2	Lothar Gremer		`false`
3	Thomas van Groen		`false`
4	Ewa A. Mirecka		`false`
5	Inga Kadish		`false`
6	Antje Willuweit		`false`
7	Janine Kutzsche		`false`
8	Dagmar Jürgens		`false`
9	Stephan Rudolph		`false`
10	Markus Tusche		`false`
11	Patrick Bongen		`false`
12	Jörg Pietruszka		`false`
13	Filipp Oesterhelt		`false`
14	Karl-Josef Langen		`false`
15	Hans-Ulrich Demuth		`false`
16	Arnold Janssen		`false`
17	Wolfgang Hoyer		`false`
18	Susanne Aileen Funke	https://www.hs-coburg.de/personen/prof-dr-susanne-aileen-funke/	`true`
19	Luitgard Nagel-Steger		`false`
20	Dieter Willbold		`false`

⇄⧉ titel => UTF-8 string (87) "QIAD assay for quantitating a compound`s efficacy in elimination of toxic Aß... $post['titel']

QIAD assay for quantitating a compound`s efficacy in elimination of toxic Aß oligomers

⇄medien => string (18) "Scientific reports" $post['medien']

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⇄⧉ abstract => UTF-8 string (681) "Strong evidence exists for a central role of amyloid ß-protein (Aß) oligomer... $post['abstract']

Strong evidence exists for a central role of amyloid ß-protein (Aß) oligomers in the pathogenesis of Alzheimer`s disease. We have developed a fast, reliable and robust in vitro assay, termed QIAD, to quantify the effect of any compound on the Aß aggregate size distribution. Applying QIAD, we studied the effect of homotaurine, scyllo-inositol, EGCG, the benzofuran derivative KMS88009, ZAß3W, the D-enantiomeric peptide D3 and its tandem version D3D3 on Aß aggregation. The predictive power of the assay for in vivo efficacy is demonstrated by comparing the oligomer elimination efficiency of D3 and D3D3 with their treatment effects in animal models of Alzheimer´s disease.

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⇄⧉ zitierung => UTF-8 string (539) "Brener, Oleksandr; Dunkelmann, Tina; Gremer, Lothar; van Groen, Thomas; Mire... $post['zitierung']

Brener, Oleksandr; Dunkelmann, Tina; Gremer, Lothar; van Groen, Thomas; Mirecka, Ewa A.; Kadish, Inga; Willuweit, Antje; Kutzsche, Janine; Jürgens, Dagmar; Rudolph, Stephan; Tusche, Markus; Bongen, Patrick; Pietruszka, Jörg; Oesterhelt, Filipp; Langen, Karl-Josef; Demuth, Hans-Ulrich; Janssen, Arnold; Hoyer, Wolfgang; Funke, Susanne  A.; Nagel-Steger, Luitgard; Willbold, Dieter (2015): QIAD assay for quantitating a compound`s efficacy in elimination of toxic Aß oligomers. Scientific reports 2015 5, S. 13222. DOI: 10.1038/srep13222

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https://www.hs-coburg.de/publikation/1928-qiad-assay-for-quantitating-a-compound-s-efficacy-in-elimination-of-toxic-ass-oligomers/

The website of Coburg University of Applied Sciences was translated using translation software provided by a third-party provider such as DeepL. The official text is the German version of the website. No liability is assumed, either explicitly or implicitly, for the accuracy, reliability, or correctness of the translations into another language.

QIAD assay for quantitating a compound`s efficacy in elimination of toxic Aß oligomers

Strong evidence exists for a central role of amyloid ß-protein (Aß) oligomers in the pathogenesis of Alzheimer`s disease. We have developed a fast, reliable and robust in vitro assay, termed QIAD, to quantify the effect of any compound on the Aß aggregate size distribution. Applying QIAD, we studied the effect of homotaurine, scyllo-inositol, EGCG, the benzofuran derivative KMS88009, ZAß3W, the D-enantiomeric peptide D3 and its tandem version D3D3 on Aß aggregation. The predictive power of the assay for in vivo efficacy is demonstrated by comparing the oligomer elimination efficiency of D3 and D3D3 with their treatment effects in animal models of Alzheimer´s disease.

Titel:

QIAD assay for quantitating a compound`s efficacy in elimination of toxic Aß oligomers

Veröffentlichungsdatum:

01.01.2015

Publikationsart:

Zeitschriftenbeiträge

Forschungsschwerpunkt:

Medien:

Scientific reports

DOI:

https://doi.org/10.1038/srep13222

Weblink:

Heft:

Band:

2015 5

Artikelnummer:

ISBN:

Autoren:

Oleksandr Brener, Tina Dunkelmann, Lothar Gremer, Thomas van Groen, Ewa A. Mirecka, Inga Kadish, Antje Willuweit, Janine Kutzsche, Dagmar Jürgens, Stephan Rudolph, Markus Tusche, Patrick Bongen, Jörg Pietruszka, Filipp Oesterhelt, Karl-Josef Langen, Hans-Ulrich Demuth, Arnold Janssen, Wolfgang Hoyer, Susanne Aileen Funke, Luitgard Nagel-Steger, Dieter Willbold

Medien:

Scientific reports

Herausgeber:

Seiten:

13222

Open Access:

Peer reviewed:

Zitierung:

Brener, Oleksandr; Dunkelmann, Tina; Gremer, Lothar; van Groen, Thomas; Mirecka, Ewa A.; Kadish, Inga; Willuweit, Antje; Kutzsche, Janine; Jürgens, Dagmar; Rudolph, Stephan; Tusche, Markus; Bongen, Patrick; Pietruszka, Jörg; Oesterhelt, Filipp; Langen, Karl-Josef; Demuth, Hans-Ulrich; Janssen, Arnold; Hoyer, Wolfgang; Funke, Susanne A.; Nagel-Steger, Luitgard; Willbold, Dieter (2015): QIAD assay for quantitating a compound`s efficacy in elimination of toxic Aß oligomers. Scientific reports 2015 5, S. 13222. DOI: 10.1038/srep13222

Autoren:

QIAD assay for quantitating a compound`s efficacy in elimination of toxic Aß oligomers

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